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Jeffrey Ecsedy Selected Research

MLN8054

4/2011Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors.
10/2010Phase I study of the selective Aurora A kinase inhibitor MLN8054 in patients with advanced solid tumors: safety, pharmacokinetics, and pharmacodynamics.
11/2008Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells.

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Jeffrey Ecsedy Research Topics

Disease

18Neoplasms (Cancer)
01/2022 - 11/2008
3Adenocarcinoma
07/2017 - 03/2012
3Stomach Neoplasms (Stomach Cancer)
01/2017 - 12/2013
3Polyploidy
02/2013 - 12/2002
2Gastrointestinal Neoplasms (Gastrointestinal Cancer)
01/2019 - 12/2013
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2019
1Chromosomal Instability (Chromosome Stability)
10/2019
1Lung Neoplasms (Lung Cancer)
10/2019
1Adenoma (Adenomas)
01/2019
1Colonic Neoplasms (Colon Cancer)
01/2019
1Ovarian Neoplasms (Ovarian Cancer)
11/2017
1Carcinogenesis
12/2013
1Inflammation (Inflammations)
12/2013
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2012
1Chromosome Aberrations (Chromosome Abnormalities)
09/2012
1Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
09/2012
1Ewing Sarcoma (Sarcoma, Ewing)
11/2011
1Neuroblastoma
11/2011
1Stomatitis
10/2010
1Sleepiness
10/2010
1Multiple Myeloma
06/2010
1Infertility (Sterility)
12/2002

Drug/Important Bio-Agent (IBA)

16Aurora Kinase AIBA
10/2019 - 11/2008
12MLN 8237IBA
10/2019 - 06/2010
3Cisplatin (Platino)FDA LinkGeneric
01/2017 - 03/2012
3MLN8054IBA
04/2011 - 11/2008
2Eukaryotic Initiation Factor-4EIBA
07/2017 - 01/2017
2Proteins (Proteins, Gene)FDA Link
01/2014 - 02/2013
1liposomal doxorubicin (Doxil)FDA Link
01/2022
1Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
01/2022
1KynurenineIBA
01/2022
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
10/2019
1ParaffinIBA
01/2019
1Phenobarbital (Luminal)FDA Link
01/2019
1Ribosomal Protein S6 Kinases (S6 Kinase)IBA
01/2019
1Caspase 3 (Caspase-3)IBA
01/2019
1Biomarkers (Surrogate Marker)IBA
01/2018
1Paclitaxel (Taxol)FDA LinkGeneric
11/2017
1Codon (Codons)IBA
11/2017
1EverolimusFDA Link
07/2017
1Peptide Initiation Factors (Initiation Factor)IBA
01/2017
1PlatinumIBA
01/2017
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2013
1Phosphotransferases (Kinase)IBA
12/2013
1LuciferasesIBA
12/2013
1Docetaxel (Taxotere)FDA Link
02/2013
1Messenger RNA (mRNA)IBA
03/2012
1Antineoplastic Agents (Antineoplastics)IBA
03/2012
1Aurora KinasesIBA
12/2011
1ChromatinIBA
12/2002

Therapy/Procedure

4Therapeutics
01/2018 - 06/2010
2Aftercare (After-Treatment)
02/2013 - 03/2012
1Radiotherapy
10/2019
1Infusion Pumps (Infusion Pump)
07/2014